Сòòò½APP

Remain competitive and avoid costly missteps in lead candidate selection and advancement with efficient DMPK/ADME testing. Get data back faster without sacrificing thoroughness or quality with rapid turnaround times. Rapidly test preclinical and clinical samples with a host of available in vitro ADME assays, in addition to custom method development. 

From selecting a candidate with an appropriate ADME profile to monitoring its bioavailability throughout clinical trials, our team serves as a true partner and full-service DMPK CRO. Both in vitro and in vivo samples are accepted. Get a quote from our DMPK lab. 

Comprehensive DMPK and ADME testing

It’s as simple as sending animal or human samples; our bioanalytical laboratory will do the rest — saving precious time and internal lab resources, which can be devoted elsewhere. Сòòò½APP's DMPK/ADME expertise extends to a broad collection of analytical techniques beyond immunoassays and ELISAs.

• Novel DMPKE/ADME assay development and validation
• DMPK-toxicology studies when integrated with toxicity services
• DMPK & ADME method transfer and sample analysis
• High throughput therapeutic drug monitoring (TDM)

Connect with Сòòò½APP's DMPK lab today.

DMPK/ADME assay methods

Jumpstart progress with well-established in vitro ADME assays, quickly adapted to specific drug candidates, providing an early glimpse at the candidate’s DMPK behavior and supporting IND-submissions. These methods evaluate dosage regimens, compare administration routes, and perform basic safety assessments on animal model samples supplied by pharmaceutical partners.

Methods are quickly activated, and sample analysis begins without delay. Novel DMPK/ADME assay methods are designed and developed if a more specific or refined experimental approach is required. Our partners can then choose whether they’d like to transfer this method elsewhere, such as to internal sites, or have us execute sample analysis.

ADME assessments can be fully integrated with toxicity services to provide a full framework for DMPK-toxicology studies. Interested in novel DMPK services and ADME testing? Contact our experts.

Therapeutic drug monitoring (TDM)

Ensure drug effectiveness and subject safety when you partner with us to regularly measure drug concentrations in serum or plasma. High-throughput capacity and accelerated workflows keep up with therapeutic drug monitoring (TDM) result demand throughout the course of trials.

We are committed to delivering efficient turnaround times and quality reporting, given the need for rapid and routine testing of patient samples to ensure drug levels are neither too high nor too low. Drug candidates requiring TDM have a particularly narrow therapeutic index, and small variations in dose or concentration can lead to therapeutic failures or harmful side effects. You can trust us to regularly measure drug concentrations in serum or plasma to ensure drug effectiveness and subject safety. Request a quote from our TDM lab today.

The Сòòò½APP advantage

A wide range of innovative ADME and DMPK solutions and services are customized to meet the needs of early and late-stage discovery programs. Validate toxicology studies, determine the likelihood of drug-drug interactions, and obtain high-quality data to support safety evaluations when you partner with Сòòò½APP. For more information about our ADME and DMPK lab testing services or to request a quote, contact us today.